Drug Discovery, Development and Posology
Drug discovery is the process by which new applicant medications are discovered. Traditionally, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Advanced chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology.
Drug development is the process of getting a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It comprises pre-clinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate medical trials on humans, and may include the step of obtaining regulatory approval with a new drug application to market the drug. Posology is defined as the pharmacological determination of appropriate doses of drugs and medicines.
- Screening and Design
- Nature as source
- Microbial metabolites
- Structural elucidation
- Chronopharmacology and its effects
- Study on physiology and biochemical response
- Systemic biology & molecular pathology
- Genomics and social aspects
- Advancement using nanotechnology
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