Neuroimmunology and Neuroinflammation

Neuroimmunology is a field of combining neuroscience, the study of the nervous system and immune system. Neuroimmunologists seek to better understand the interactions of  two complex systems during development, homeostasis, and response to injuries. Neuroimmunology contributes to the development of new pharmacological treatments for several neurological conditions. Nervous and immune systems involve many types of interactions, including the physiological functioning of the two systems in health and disease, malfunction of either and or both systems that leads to disorders, and the physical, chemical, and environmental stressors that affect the two systems on a daily basis.

Neuroinflammation is inflammation of the nervous tissue and it may be initiated in response to a variety of cues, including infection, traumatic brain injury, toxic metabolites, or autoimmunity. The CNS is usually an immunologically privileged site because peripheral immune cells are generally blocked by the blood–brain barrier. Though, circulating peripheral immune cells may surpass a compromised BBB and encounter neurons and glial cells expressing major histocompatibility complex molecules, perpetuating the immune response. While the response is initiated to protect the central nervous system from the infectious agent, the effect may be toxic and widespread inflammation as well as further migration of leukocytes through the blood–brain barrier.

  • Pleocytosis
  • Neuroimmunity
  • Neuroprotection
  • Microglial activation
  • Proinflammatory B-cell
  • Myasthenia gravis (MG)
  • Herpes simplex encephalitis
  • Meningeal carcinomatosis
  • Brain inflammation detectors
  • Characterization of lymphopenia
  • Systemic inflammatory response syndrome
  • Central nervous system demyelinating disorders
  • Neuroimmunology of OMS and ANNA-1/anti-Hu paraneoplastic syndromes

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