Rameshwar K Sharma
Salus University, USA
Biography
After his undergraduate work in the Birla Institute Pilani, India, Dr. Sharma received his Ph.D. from the University of Connecticut. His research is dedicated to the advancement of the field of membrane guanylate cyclases (MGCs). Discovery of the first membrane guanylate cyclase, ANF-RGC, established cyclic GMP as an intracellular hormonal second messenger. Discovery of others demonstrated that the operational principles of the MGCs transduction mechanisms are complex and unique to each form. Contrary to the other two signaling systems, cyclic AMP and IP3, cyclic GMP pathway dispenses with intermediaries. The hormone binds to an MGC and catalyzes its activity directly. The pathway is multifaceted, its molecular design incorporates multiple regulations: by ATP, Ca2+-sensing subunits and atmospheric carbon dioxide. These diverse effectors confer MGC cellular specificity and multi-switching signaling attributes linked with the physiology of cardiac vasculature, smooth muscle relaxation, blood pressure regulation, cellular growth, sensory transductions, neural plasticity and memory.
Abstract
Abstract : Membrane guanylate cyclase: A multimodal cell signaling switch