Neuropharmacology

Biography

Jean-Pierre Mothet is Director of Research at CNRS (France). He graduated from the University Pierre and Marie Curie, Paris, in 1996 working with Dr. Ladislav Tauc. Then, he pursued Post-doctoral research with Pr Solomon H. Snyder at The Johns Hopkins School of Medicine (USA). There he elucidated the functions and the synthesis pathway of brain D-serine. In 1999, he moved to the laboratory of Pr Jacopo Meldolesi (Italy) to study exocytosis of neurotransmitters. His team “Gliotransmission and Synaptopathies” investigates the regulation of NMDA receptors at synapses and circuits underlying memory formation in the context of healthy and pathological neuron-glia interactions. He also explores the mechanisms underlying gliotransmission, the process by which glia releases chemical messengers, and the functional relevance for neuronal network dynamics. He serves at the Editorial board Member of Frontiers in Synaptic Neuroscience and PlosONE and he is a member of the ESN council.

Abstract

Abstract : The D-serine signalling pathway: A druggable target for treating synaptopathies