Neuropharmacology

Biography

Biography: Zeynab-Sadat Payambarpour

Abstract

Many chemicals or substances might be associated with inflammation-induced angiogenesis which have not been discovered yet. So far we know some of the pheromones can reduce inflammation. Currant borer, Synanthedon tipuliformis, (Sesiidae); leopard moth, Zeuzera pyrina L. and pistachio twig borer, Kermania pistaciella (Lepidoptera: Oinophilidae) are three pest insects with well-known sex pheromones whose main active components of their sex pheromones are E2,Z13-18:OAc; (E, Z)-2, 13-octadecadien-1-ol acetate and (2S,12Z)-2-acetoxy-12-heptadecene, respectively, together with a series of lipid derivatives. We hypothesized that these pheromones may contain angiogenesis modulators. In the current study, we investigated the effects of the pheromones alone or in combination with paclitaxel on angiogenesis in chorioallantoic membrane. These pheromones demonstrated potent in vivo anti-angiogenic activity, which exceeded that of their solvents as reference agents. All tested pheromones showed the most potent anti-angiogenic activity, which was twice that of their solvents, as well combination of all of them with paclitaxel induced the most potent anti-angiogenic effect. This highlights the importance of identifying pro- and anti-angiogenic property in these pheromones not only for the development of novel angiogenesis modulators for the treatment of diseases such as cancer, but also their use as adjuvants for chemotherapy agents.