Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series : World's leading Event Organizer

Back

Arieh S Solomon

Arieh S Solomon

Tel Aviv University , Israel

Title: Prolonged inhibition of semaphorin3a pathway via biodegradable implant towards a better therapy for visual sensory impairments

Biography

Biography: Arieh S Solomon

Abstract

Background: Semaphorin 3A is a leading factor in the apoptotic death program of the neural cells in CNS. It is right to suppose that inhibition of Sema3A expression in the right time window will reduce the death of a great population of neural cells following assault.      

Purpose: To develop low molecular weight inhibitor of Sema3A and produce function blocking Sema3A human antibodies  Manufacture a biodegradable polymeric implant for controlled release of Sema3A inhibitor.                

Material and Methods: We used laboratory rats and rabbits and created acute and chronic assault to the optic nerve. Following the assault we injected the substances mentioned above in the injured eye.  

Results: We present the methods of creating the low MW inhibitors of Sema3A and the Sema3A antibodies. The creation of the implants is shown. We present here the positive inhibitory activity of these substances in vitro and in vivo experiments.Â