Arieh S Solomon
Tel Aviv University , Israel
Title: Prolonged inhibition of semaphorin3a pathway via biodegradable implant towards a better therapy for visual sensory impairments
Biography
Biography: Arieh S Solomon
Abstract
Background: Semaphorin 3A is a leading factor in the apoptotic death program of the neural cells in CNS. It is right to suppose that inhibition of Sema3A expression in the right time window will reduce the death of a great population of neural cells following assault. Â Â Â
Purpose: To develop low molecular weight inhibitor of Sema3A and produce function blocking Sema3A human antibodies  Manufacture a biodegradable polymeric implant for controlled release of Sema3A inhibitor.        Â
Material and Methods: We used laboratory rats and rabbits and created acute and chronic assault to the optic nerve. Following the assault we injected the substances mentioned above in the injured eye. Â
Results: We present the methods of creating the low MW inhibitors of Sema3A and the Sema3A antibodies. The creation of the implants is shown. We present here the positive inhibitory activity of these substances in vitro and in vivo experiments.Â
