Gafarov Valery
Collaborative laboratory of cardiovascular diseases epidemiology, Russia
Title: Association of polymorphism rs2412646 clock gene with some socio-psychological features and sleep disorders in male population 25-44 years in Russia / Siberia
Biography
Biography: Gafarov Valery
Abstract
Objective: to study the prevalence and association of rs2412646 gene CLOCK with some components of the socio-psychological characteristics and sleep disorders in the male population 25-44 years in Russia / Siberia (Novosibirsk).
Materials and methods. In 2014-2016 GG It surveyed a random representative sample of the male population 25-44 years, one of the districts of Novosibirsk. Randomly selected 200 men had a mean age of 35.5 years, who underwent psychosocial testing. Testing conducted by questionnaire "4-item Jenkins Sleep Questionnaire». Test anxiety and depression conducted modified questionnaires of the Welsh Depression subscale of the MMPI and Bendig Anxiety subscale of the MMPI, the study of the life of exhaustion conducted questionnaires The Maastricht Questionnaire (MQ). Questionnaire "Awareness and attitude towards their health" was also proposed. The men included in the study, studied the frequency distribution of genotypes of rs2412646 CLOCK gene. Differences in the distribution of genotype frequencies CLOCK gene were evaluated by Chi square (X2) test between groups. The values of p ≤ 0,05 were considered statistically significant.
Results. It was found that the most common genotype in the population was the C / C gene CLOCK -50,3%, C / T met at 42.5% and genotype T / T all at 7.2%. Most of the men were of the opinion, that would be addressed to the doctor only when severe pain or discomfort in the heart, but would not return if the pain or discomfort would be poorly expressed, however, 10.7% of men, the carriers of the genotype C / T, I would not go to a doctor, even when a severe pain or unpleasant sensations in the heart. It is also more likely to have continued to work carriers of genotype C / T - 47,4%. Among the carriers C / T genotype often sounded that their sleep is "satisfactory" or "poor." Media C / T genotype, compared with carriers of other genotypes, most agreed with the statement that oppresses them in a bad mood, and they are much less careful and attentive to detail.
Conclusion: Our results indicate a correlation between the presence of social and psychological factors, and sleep disorders, and polymorphic markers rs2412646 CLOCK gene.