Kaveh Shafiei
Kerman University of Medical sciences, Iran
Title: Topiramate induced paresthesia is more frequently reported by migraine than epileptic patients
Biography
Biography: Kaveh Shafiei
Abstract
Background: Topiramate is an approved and effective drug in migraine prophylaxis. Paresthesia is the most commonly reported side effect. The primary objective of this study was to compare the frequency of Topiramate induced paresthesia in migraine headache to Epileptic patients. Methods: Patients with migraine without aura and epilepsy were enrolled in this observational study. All cases were interviewed by telephone about their history of paresthesia. Confounding factors were controlled through logistic regression. Results: The odd ratio of developing Topiramate induced paresthesia in migraine compared to epilepsy patients was to 3.4. Three factors were independent contributors to developing Topiramate induced paresthesia, female sex (Odd ratio 2.1), Topiramate dosage (odd ratio 0.3) and duration of therapy. Conclusion: Our findings indicate an independent association between migraine and development of paresthesia. Migraineurs were more likely than epileptic patients to report paresthesia as Topiramate adverse effects. Female sex, treatment duration and Topiramate dosage contribute significantly to subsequent development of paresthesia.