Neuropharmacology

Biography

Biography: Gianni Colini-Baldeschi

Abstract

This prospective observational study that took place over three years takes into account the metabolic parameters and capillaroscopy. The aim of our study is to identify the assessment of metabolic and dynamic capillaroscopy parameters thatmay be predictive of the outcome of SCS in patients affected with non-revascularizable chronic critical limb ischemia. Forty patients, 16 female and 24 male, average age 69±8, underwent microcirculatory screening with transcutaneous oximetry and dynamic capillaroscopy on the big toe nailfold; all patients were affected by chronic critical ischemia from atherosclerotic arterial disease, defined on the basis of the TransAtlantic Inter-Society Consensus criteria, and identified as non-revascularizable. Conservative treatment had proved to be of little or no effect. Follow-up visits were scheduled at three, six, and twelve months after implantation. The procedure was performed placing an Octrode (St. Jude Medical, St. Paul, MN, USA) on the dorsal columns of the spinal cord with the tip at T8-T9. Two groups were identified on the basis of transcutaneous oximetry measurements: group A (22 patients) and group B (18 patients), responding differently to the postural test. Patients affected by non-reconstructable chronic limb ischemia can benefit from SCS not only in terms of relief from their ischemic pain, but also of wound healing and limb salvage. Spinal neuromodulation is an effective therapy option in the management of patients affected by non-reconstructable chronic critical limb ischemia.