Neuropharmacology

Biography

Biography: Ana Claudia Nunciato

Abstract

This interface can be understood and explained from the relationship between cause and consequence, the relationship between sign, symptom, diagnosis or treatment. Thus, the objective is to correlate symptoms presented by neurological patients with a diagnosis of major depression and physical therapy. Depression is a disorder most common mood characterized by sadness, loss of interest or pleasure, feelings of guilt or low self-esteem, sleep or appetite disturbances, feeling of tiredness or fatigue and lack of concentration. A neurological disease affecting nearly 17% of the world population or 340 million people and it is estimated that in 2020 is the 2nd cause of disability according to WHO is considered. Several hypotheses have tried to explain the cause and onset of symptoms. It has been valuable in the development of conventional antidepressants that are thought to act by reversing these dysfunctional states of depression. The depression is comorbidity is present in neurodegenerative disease and in systemic diseases. All the pathologies share the same dysfunction and neurochemical changes in the central nervous system such as serotonergic hypofunction. Thus, in addition to the beneficial effects of antidepressants, the physical therapy through physical activity can stimulate neuroplasticity (synaptogenesis, enhanced glucose utilization, angiogenesis, and neurogenesis), improves psychological (social interaction) and physiological (monoamines and endorphins). The exercise and the antidepressant treatment are shown to have a strong reinforcing effect on adult neurogenesis. Therefore, the exercise and the physical therapy may be source non-pharmacology of improvement of depression.