Neuropharmacology

Biography

Biography: Pedro M R Reis

Abstract

Methodology that would allow the investigation of interactions between brain activity sources, natural motor behavior and drug interactions, would bring benefits such has personalised treatments for ADHD, and understanding of disease mechanisms. With such methods, investigators and clinicians would be able to monitor and adjust treatments of impairing motor conditions. On one hand, Pharmaco-EEG allow the inspection effects of substances in the central nervous system activity. However, Pharmaco-EEG leaves out the effects on motor behaviour and how physical exercise influences pharmacokinetics. On the other hand, electroencephalography suffers from inherited methodological problems that restrict its use during motion. Yet, this is the only light enough mobile noninvasive sensing modality with adequate temporal resolution to record brain activity on the time dimension of natural motor behaviour. Recent andvances allow for synchnous measurements of brain and body dynamics (MoBi). Combining MoBi methods with pharmacokinetic analysis results in the creation of Pharmaco-Mobile Brain Body Imaging (P-MoBi). Using source localisation to determine the cortex areas responsible for different activities, and the time resolution of the EEG for functional connectivity brain mapping, researchers may be abele to determine the changes and influences of the resulting interaction betewen exercise and medicaments on brain functions and corresponding motor performance. This talk presents the reseearch potential of P-MoBi methodologies and innovations that allow such measurements.