Neuropharmacology

Biography

Biography: Ismailova Kh

Abstract

Effects of serotonin selective reuptake inhibitor – fluoxetin – on ethological parameters of anxiety state in lifted cross-like maze in emotionally stable (ES) and emotionally non-stable (ENS) to acoustic stressful stimulus (differed by seizure reaction) male Wistar rats, which are charac¬terized by different levels of biogenic amines in the brain structures, were studied. It was shown that ENS rats are originally differed by upregulation of serotonin (5-HT) and dopamine (DA), whereas ES rats – with upregulation of noradrenaline (NA). The results showed that all animals receiving fluoxetin demonstrated increased anxiety relatively to the controls. Anxiety behavior had different forms of manifestation. It is proposed that different characters of manifestation of anxiety in the rats with different phenotypes of nervous system are related to different character of effect of 5-HT upregulation on serotonergic receptors having different presentation and expression levels in the ES and ENS rats due to original significant differences in 5-HT levels in the nervous system of these animal groups. Biochemical analysis after fluoxetin administration revealed in the ENS animals predominant downregulation of 5-HT accompanied with upregu¬lation of NA in the hypothalamus. In contrast, in the ES rats significant down-regulation of 5-HT accompanied with significant upregulation of DA, while in the frontal cortex of these animals significant upregulation of 5-HT with reciprocal downregulation of DA, involved in anxiety state control and being prominent regulator of motor activity, was noticed. So, it is proposed that fluoxetin upregulates neurochemical indexes of anxiety state due to engagement of both systems of 5-HT and catecholamines which in this case act as reciprocal ones.