Alireza Rezayi
Shahid Beheshti University of Medical Sciences, Iran
Title: Intravenous Immunoglobulins for children Refractory Epilepsy
Biography
Biography: Alireza Rezayi
Abstract
Statement of the Problem :This study was conducted to investigate the efficacy of intravenous immunoglobulin for drug-resistant seizures in children reffered to pediatric neurology clinic .
Methodology & Theoretical Orientation:A retrospective review of all children in loghman hakim hospital neurology clinic from 2012 to 2015, inclusive, with intractable epilepsy who were treated with intravenous immunoglobulin for a minimum of 3 cycles was performed. Data collected included seizure frequency, seizure and epilepsy syndrome type, propable etiology for the seizures, and. Response to intravenous immunoglobulin was defined as “positive” if either seizure freedom or ≥50% reduction of seizures was achieved.
Findings:fourteen children (8 m -12 years old) were included in the study. Treatment with intravenous immunoglobulin, the following outcomes were noted: Three were seizure-free, four had 90% reduction, two had 50% reduction,three had 30 % reduction and two had any responsivness. A total of 9 (64%) patients had a positive clinical response to IVIG treatment from baseline. Five patients (36%) were not responsive. No relationship of responsiveness to intravenous immunoglobulin with regard to age, gender, or epilepsy syndrome was detected.
Conclusion & Significance:Our study and others suggest that intravenous immunoglobulin can used in the treatment of children with drug-resistant epilepsies with potentially high efficacy and low side effect. This treatment was able to reduce multiple seizure types in a variety of epilepsy etiologies, including those of unknown cause or even inborn error of metabolism.
