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Jean Paul Lellouche

Jean Paul Lellouche

Bar-Ilan University, Israel

Title: Lanthanide cation/complex-doped -maghemite nanoparticles (NPs) - innovative surface engineering (nanoscale drug delivery) towards effective anti-Leishmania bioactivity

Biography

Biography: Jean Paul Lellouche

Abstract

Iron oxide (FexOy) nanoparticles (NPs) are widely used in numerous biotechnology applications (magnetism-driven cell separation/cell tracking, magnetic field-guided drug/gene delivery, non-invasive tissue MRI, anti-cancer hyperthermia). But serious drawbacks like challenging detrimental NPs aggregation and controlled NPs surface functionalization versatility request quite innovative solutions. Our recent R&D work in this field led to the discovery of a novel method/concept for promoting (1) the effective anti-aggregation control of 5.0-6.5 nm-sized hydrophilic super-paramagnetic maghemite (g-Fe2O3) NPs, and (2) its successful use for NPs functionalization/versatile NPs surface engineering toward siRNA-mediated gene delivery/silencing cancer/anti-parasitic therapy-relevant applications. Such an innovative multi-parametric NPs surface engineering methodology exploits both globally optimized controlled design of experiment (DoE) (i) high-power ultrasound (US)-assisted lanthanide metal Ce(III/IV) cation/complex doping, and (ii) polymer/small ligand-based NPs surface coordinative engineering towards innovative drug delivery-relating maghemite NPs. Interestingly, this powerful critical first step Ce3/4+ cation/complex-doping process enabled an effective highly positive charge control of problematic NPs aggregation and full NPs water compatibility for a wide range of bio-applications. Quite significantly, it also enables the effective development of versatile surface engineering coordinative linkages/chemistries using well-known effective Ce3/4+Ln cation/complex-based coordination capabilities via any potential Lewis basis biomolecule/organic species (hyaluronic/alginic acids, 25 kDa branched polyethyleneimine (25bPEI), anti-Leishmania pentamidine (Pent) drug, etc.) simultaneous covalent binding.

 

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Recent Publications:

 

  1. L L Israel, E Lellouche, R S Kenett, O Green, S Michaeli and J P Lellouche (2014) Ce3/4+-Cation-Functionalized Maghemite Nanoparticles Towards siRNA-Mediated Gene Silencing. J Mater Chem B. 2: 6215-6225.

 

  1. J P Lellouche, S Michaeli, L L Israel, E Lellouche and K Buchman (2014) Magnetic Inorganic Iron-Based Nanoparticles - Generalities and Use in Drug Delivery, PCT International Patent Application. WO 2014/147608A1 & PCT/IL2014/050064.

 

  1. J P Lellouche, S Michaeli, L L Israel, Y Harel, A Dolitzky and S Ostrovsky (2017) "CORE-SHELL PARTICLES COMPRISING METAL OXIDE AND LANTHANIDE ELEMENT", US Provisional Patent Application No. 62/550,726.