Neuropharmacology

D1 receptors and Posterior Striatal Dopaminergic system in the brain are - although not the only- among the main circuits involved in Parkinson’s Disease and are responsible for the major motor presentations of PD. Generally, Dopaminergic system contains different type of circuits and Dopaminergic receptors in different parts of the brain with different motor and non-motor effects. One of these various Dopaminergic functions is a critical role in the mediation of reward and reinforcement behaviors. Basically, D2 and D3 receptors within the Meso-Cortico-Limbic pathways implement these activities. Dopamine Agonists, as a group of anti-Parkinsonian medications have strong affinity for D2 and D3 receptors; so, that is easy to estimate various type of behavioral side effects and complications of these medications. Dopamine Dysregulation Syndrome (DDS) beside the Impulse Control Behavior (ICB) and Dopamine Agonists Withdrawal Syndrome (DAWS) are important and bothering complications of ordering and discontinuing of this drugs respectively. Each one of these complications and their management’s methods have their own specific features, which we should be familiar. During this session we will discuss about addiction and withdrawal of Dopamine agonists in detail.